From en.wikipedia.org:
[Protein-coding gene in humans] [name-list-style=vanc] [Infobox_gene] COP9
SIGNALOSOME COMPLEX SUBUNIT 6 is a protein that in humans is encoded by the
_COPS6_ gene.[1]
** Function
The protein encoded by this gene is one of the eight subunits of COP9
signalosome, a highly conserved protein complex that functions as an important
regulator in multiple signaling pathways. The structure and function of COP9
signalosome is similar to that of the 19S regulatory particle of 26S
proteasome. COP9 signalosome has been shown to interact with SCF-type E3
ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases.
This protein belongs to translation initiation factor 3 (eIF3) superfamily.
It is involved in the regulation of cell cycle and likely to be a cellular
cofactor for HIV-1 accessory gene product Vpr.[2]
** Interactions
COPS6 has been shown to interact with EIF3S6.<ref name=pmid12220626>[ vauthors
= Hoareau Alves K, Bochard V, Réty S, Jalinot P ]
** References
[reflist]
** Further reading
[ 2]
- [ vauthors = Wolf DA, Zhou C, Wee S ]
- [ vauthors = Muthumani K, Choo AY, Premkumar A, Hwang DS, Thieu KP, Desai BM, Weiner DB ]
- [ vauthors = Mittmeyer HJ ]
- [ vauthors = He J, Choe S, Walker R, Di Marzio P, Morgan DO, Landau NR ]
- [ vauthors = Re F, Braaten D, Franke EK, Luban J ]
- [ vauthors = Di Marzio P, Choe S, Ebright M, Knoblauch R, Landau NR ]
- [ vauthors = Jowett JB, Planelles V, Poon B, Shah NP, Chen ML, Chen IS ]
- [ vauthors = Zhao LJ, Mukherjee S, Narayan O ]
- [ vauthors = Poon B, Jowett JB, Stewart SA, Armstrong RW, Rishton GM, Chen IS ]
- [ vauthors = Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG, Hershey JW ]
- [ vauthors = Mahalingam S, Ayyavoo V, Patel M, Kieber-Emmons T, Kao GD, Muschel RJ, Weiner DB ]
- [ vauthors = Seeger M, Kraft R, Ferrell K, Bech-Otschir D, Dumdey R, Schade R, Gordon C, Naumann M, Dubiel W ]
- [ vauthors = Wei N, Tsuge T, Serino G, Dohmae N, Takio K, Matsui M, Deng XW ]
- [ vauthors = Elder RT, Yu M, Chen M, Edelson S, Zhao Y ]
- [ vauthors = Ramanathan MP, Ayyavoo V, Weiner DB ]
- [ vauthors = Bech-Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, Dubiel W ]
- [ vauthors = Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ ]
- [ vauthors = Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y ]
- [ vauthors = Hrimech M, Yao XJ, Branton PE, Cohen EA ]
[refend]
** External links
- [COPS6]
[gene-7-stub]