From The Jargon File (version 4.4.7, 29 Dec 2003):
lose
vi.
1. [very common] To fail. A program loses when it encounters an exceptional
condition or fails to work in the expected manner.
2. To be exceptionally unesthetic or crocky.
3. Of people, to be obnoxious or unusually stupid (as opposed to ignorant).
See also deserves to lose.
4. n. Refers to something that is losing, especially in the phrases “
That's a lose!” and “What a lose!”