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Found 2 definitions

  1.                 From The Collaborative International Dictionary of English v.0.48:
                    

    Quarto \Quar"to\, n.; pl. Quartos. Originally, a book of the size of the fourth of sheet of printing paper; a size leaves; in present usage, a book of a square or nearly square form, and usually of large size. [1913 Webster]

  2.                 From The Collaborative International Dictionary of English v.0.48:
                    

    Quarto \Quar"to\, a. [L. in quarto in fourth, from quartus the fourth: cf. F. (in) quarto. See Quart.] Having four leaves to the sheet; of the form or size of a quarto. [1913 Webster]